UNICEF has a program called Inspired Gifts that makes a great way to give during the holidays. Here is some info from their website.

What are Inspired Gifts?
Inspired Gifts is an innovative program that gives you the opportunity to purchase actual life-saving items that will be shipped directly from both the UNICEF warehouse in Copenhagen and one of UNICEF's many suppliers to one of over 150 countries where UNICEF serves. While other organizations allow supporters to purchase ‘symbolic’ gifts, Inspired Gifts are actual items like warm blankets, mosquito nets, water wells, therapeutic milk, even School-in-a-Box kits. In a world where everyday 21,000 children die from preventable causes, Inspired Gifts can make an immediate and dramatic difference in the life of a child threatened by malnutrition, disease, unclean water, lack of shelter, basic immunizations and basic medicines.
http://inspiredgifts.unicefusa.org/site ... g_homepage