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Thread: [FutureBuddha (18)] The Buddhist Three Poisons: A Substitute for Harmful Intoxicants

  1. #1

    [FutureBuddha (18)] The Buddhist Three Poisons: A Substitute for Harmful Intoxicants



    Any tool can be used for good or bad ... such as a hammer, which can be used as a weapon and to kill, or to build houses for the homeless. I am totally against any tool if there is great potential to use it for harm, or for it to fall into bad hands. I am for any tool that can be used for good things, and used safely. And if we must have hammers, and they are unavoidable, then I push for the latter case of good and safe uses.

    I am not about "genes genes genes," far from it. It is actually a small part of what I am discussing. I reject that technology now, and for any time in the future, unless and until it someday, somehow, with further advances, becomes as safe as a "tummy tuck" at the plastic surgeon or a root canal or hip replacement. But that seems unlikely. Gene therapy is too dangerous now for common use, and will remain so for a long time, assuming that it ever becomes safe and effective. If it did become possible, and the technology unavoidable, only them should we use the technology wisely and for good.

    Instead, I am for the use of any and every tool, from hammers to other wonderful tools of the near future which science and medicine will provide, which can be used for good. My book touches on many such tools, and there are many ways to improve society, lessen killing and violence, increase charity and caring that have nothing to do with genetics at all. One of my favorites imaginings is an alcohol or other substance that is non-addictive (and might even have addiction curative properties), where the "high" can be turned off at will, where the inebriation always stays at "pleasant" and never runs to "fall off the stool, bar fight, get behind the wheel, beat your spouse angry," where the loving and friendly aspects stay, but not the negative excesses. (Yes, I know that Star Trek was way ahead of me on this. ) A simple change like that, and a cure for physiological addictions, would save so many millions of ruined lives in this world, and do much to combat the Buddhist poisons of anger, violence, addiction ...

    Does it sound like fantasy?

    Well, I hope that Dr. Nutt is not a nut ...

    One of the U.K.’s leading neuropsychopharmacologists has published an op-ed in The Guardian detailing his research efforts to come up with a synthetic, non-addictive substitute for alcohol. David Nutt’s hope is to do for alcohol what e-cigarettes have done for smoking. Nutt has identified five chemical compounds that target the same neurotransmitter system in the brain as alcohol, leaving people feeling relaxed and friendly. These compounds also present the possibility for concocting an antidote that would instantly sober you up.

    ... "We know that the main target for alcohol in the brain is the neurotransmitter system gamma aminobutyric acid (Gaba), which keeps the brain calm. Alcohol therefore relaxes users through mimicking and increasing the Gaba function. But we also know that there are a range of Gaba subsystems that can be targeted by selective drugs. So in theory we can make an alcohol surrogate that makes people feel relaxed and sociable and remove the unwanted effects, such as aggression and addictiveness." ...

    https://www.theguardian.com/commenti...s-closer-think
    Professor David Nutt keeps a litre bottle behind him on the shelf in his office. Inside is a molecular compound called Alcarelle that he has spent two years developing in an underground lab with fellow scientists. He hopes it will soon, if approved by regulators, allow people to get a bit drunk, without any of the downsides.

    As an alternative to ethanol, the core ingredient of most alcoholic drinks, Nutt claims that synthetic alcohol Alcarelle would see people enjoying the positive effects of booze – the buzz, the relaxation, the lowering of inhibitions when talking to strangers at a party – without the health implications, without losing control, and without the dread-filled hangovers.

    “Alcohol is my favourite drug, and it has the huge benefit of helping us socialise as humans, but we’ve been brainwashed by the drinks industry into thinking that it’s not bad for us,” says 71-year-old Nutt, professor of neuropsychopharmacology at Imperial College London, who was the UK Government’s drugs adviser under New Labour but was sacked in 2009 by home secretary Alan Johnson for claiming that alcohol is more dangerous than ecstasy or LSD.

    https://inews.co.uk/inews-lifestyle/...nsides-2088768
    Once again, it is imperative that the medical establishment do test, thorough clinical trials, to make sure that this hammer is safe ...

    The concept of synthetic alcohol has potential, says Margie Skeer, an associate professor of public health and community medicine at the Tufts University School of Medicine. “Any time that we can reduce harm associated with the things that we do on a daily basis is a positive thing.” However, “the public really needs to be cautious with new products that promise all of the good of a vice without the negative side effects,” she says. “We don’t have any research. We don’t have any data.”

    https://time.com/6131012/synthetic-a...alth-benefits/
    And non unexpectedly, he is also meeting resistance from "Big Brewery" interests ...

    Gassho, J

    stlah





    Last edited by Jundo; 03-10-2023 at 02:51 AM.
    ALL OF LIFE IS OUR TEMPLE

  2. #2
    Something like this would also be lovely, in the news this week ...

    A study conducted by OHSU and other research institutions nationwide has yielded promising results for a new treatment of alcohol use disorder.
    A team of researchers from Oregon Health & Science University and various institutions nationwide have discovered a medication, commonly used for treating a skin condition, as a highly promising treatment for alcohol use disorder.

    The study was recently published in the Journal of Clinical Investigation.

    The individuals who were treated with apremilast, on average, showed a decrease in their daily alcohol consumption by over 50 percent, reducing their intake from five drinks per day to two.

    “I’ve never seen anything like that before,” said co-senior author Angela Ozburn, Ph.D., associate professor of behavioral neuroscience in the OHSU School of Medicine and a research biologist with the Portland VA Health Care System.


    ... Beginning in 2015, Ozburn and collaborators searched a genetic database looking for compounds likely to counteract the expression of genes known to be linked to heavy alcohol use. Apremilast, an FDA-approved anti-inflammatory medication used to treat psoriasis and psoriatic arthritis, appeared to be a promising candidate.

    They then tested it in two unique animal models that have a genetic of risk for excessive drinking, as well as in other strains of mice at laboratories across the country. In each case, apremilast reduced drinking among a variety of models predisposed to mild to heavy alcohol use. They found that apremilast triggered an increase in activity in the nucleus accumbens, the region of the brain involved in controlling alcohol intake.

    Researchers at the Scripps Research Institute in La Jolla, California, then tested apremilast in people.

    The Scripps team conducted a double-blind, placebo-controlled clinical proof-of-concept study involving 51 people who were assessed over 11 days of treatment. ...

    ... An estimated 95,000 people in the United States die every year from alcohol-related deaths, according to the National Institute on Alcohol Abuse and Alcoholism. ...

    https://scitechdaily.com/ive-never-s...sive-drinking/
    Gassho, J

    stlah
    ALL OF LIFE IS OUR TEMPLE

  3. #3
    And non unexpectedly, he is also meeting resistance from "Big Brewery" interests ...
    I sadly think that this is inevitable. As you pointed out to me, the Paris Climate agreement was not all that it should/could have been and the reason for that was committed lobbying by fossil fuel interests and companies whose economies are hugely reliant on oil and gas.

    I suspect that vested interests are going to react similarly to developments that could be considered positive for humanity in general, yet threaten their own profits. Whether that is sufficient to stop progress depends on the size of the vested interest and strength of world leaders. At present, many world leaders seem far too cosy with big business.

    Gassho
    Kokuu
    -sattoday-

  4. #4
    Quote Originally Posted by Kokuu View Post
    Whether that is sufficient to stop progress depends on the size of the vested interest and strength of world leaders. At present, many world leaders seem far too cosy with big business.
    and with drinking themselves, i am afraid..


    aprapti


    sat

    hobo kore dojo / 歩歩是道場 / step, step, there is my place of practice

    Aprāpti (अप्राप्ति) non-attainment

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